Archive for November, 2008

Conserved sequence

Sunday, November 30th, 2008

In biology, conserved sequences are similar or identical sequences that may occur within nucleic acids, proteins or polymeric carbohydrates within multiple species of organism or within different molecules produced by the same organism. In the case of cross species conservation, this indicates that a particular sequence may have been maintained by evolution despite speciation. The further back up the phylogenetic tree a particular conserved sequence may occur the more highly conserved it is said to be.

Chemical Derivation of Acetylcarnitine

Sunday, November 30th, 2008

Acetyl-L-Carnitine is L-Carnitine, acetylated.

L-carnitine is derived from the lysine and methionine amino acids.

Beaver Buzz

Sunday, November 30th, 2008

Beaver Buzz is an energy drink produced in Canada by DD Beverage Company of British Columbia. Ingredients of the product line include taurine, caffeine, Siberian Ginseng, Guarana seed extract and various vitamins, but avoids the use of high fructose corn syrup.[1] Sizes include 355 millilitres (12.0 US fl oz/12.5 imp fl oz) and the Big Buzz brand of 473 millilitres (16.0 US fl oz/16.6 imp fl oz). Product variations include citrus, green tea and Saskatoon berry flavours.[2]

The beverage is distributed by retailers in all regions of Canada[3][4] and was noted in national[3] and regional[5] press coverage. However, DD Beverage has encountered difficulty delivering its product into the United States despite the implementation of the North American Free Trade Agreement.[6] The Buzz Energy brands also trade in the United Kingdom as Bulldog Buzz.[7]

Double D Beverage Company, advertising as Buzz Energy, was founded by Andrew Drayson, James Drayson, and Richard DeBanks.

Physical origins of Anomeric effect

Sunday, November 30th, 2008

The simplest explanation is that the equatorial configuration has the dipoles involving both heteroatoms partially aligned, and therefore repelling each other. By contrast the axial configuration has these dipoles roughly opposing, thus representing a more stable and lower energy state.

In 1998, Box’s molecular modeling studies of saccharides, and analysis of crystallographic data of monosaccharides from the Cambridge Crystallographic Database, using the molecular mechanics based program STR3DI32, resulted in a refinement of this dipolar hypothesis by showing that the dipolar repulsions originally suggested, above, were reinforced by stabilizing, and significant, C-H…O hydrogen bonds involving the acetal functional group.[3] More recent MO calculations are consistent with this hypothesis.[4] This more comprehensive analysis of the origins of the anomeric effect has also resulted in a better understanding of the related, and equally puzzling, reverse anomeric effect.[5]

An alternative and widely accepted explanation is that there is a stabilizing interaction (hyperconjugation) between the unshared electron pair on the one heteroatom (the endocyclic one in a sugar ring) and the ?* orbital for the axial (exocyclic) C–X bond. When the exocyclic (in a sugar) atom bears a lone pair of electrons there should also be a similar interaction between that unshared electron pair (of this exocyclic atom) and the ?* orbital of the annular C-O bond. This second interaction, which is a strong feature of the ?-anomer (equatorial exocyclic group), should significantly attenuate the anomeric effect. However, it is well known that when the exocyclic atoms bear lone pairs of electrons, the anomeric effect is maximal.
Some authors also question the validity of this model based on results from the theory of atoms in molecules.[6]

While most studies on the anomeric effects have been theoretical in nature, the n–?* hypothesis has also been extensively criticized on the basis that the electron density redistribution in acetals proposed by this hypothesis, is not congruent with the known experimental chemistry of acetals, and, in particular, the chemistry of monosaccharides.[7] [8]

Beaver Buzz

Sunday, November 30th, 2008

Beaver Buzz is an energy drink produced in Canada by DD Beverage Company of British Columbia. Ingredients of the product line include taurine, caffeine, Siberian Ginseng, Guarana seed extract and various vitamins, but avoids the use of high fructose corn syrup.[1] Sizes include 355 millilitres (12.0 US fl oz/12.5 imp fl oz) and the Big Buzz brand of 473 millilitres (16.0 US fl oz/16.6 imp fl oz). Product variations include citrus, green tea and Saskatoon berry flavours.[2]

The beverage is distributed by retailers in all regions of Canada[3][4] and was noted in national[3] and regional[5] press coverage. However, DD Beverage has encountered difficulty delivering its product into the United States despite the implementation of the North American Free Trade Agreement.[6] The Buzz Energy brands also trade in the United Kingdom as Bulldog Buzz.[7]

Double D Beverage Company, advertising as Buzz Energy, was founded by Andrew Drayson, James Drayson, and Richard DeBanks.

Anomeric effect

Sunday, November 30th, 2008

In organic chemistry, the anomeric effect or Edward-Lemieux effect is a stereoelectronic effect that describes the tendency of heteroatomic substituents adjacent to a heteroatom within a cyclohexane ring to prefer the axial orientation instead of the less hindered equatorial orientation that would be expected from steric considerations.[1] This effect was originally observed in pyranose rings by J. T. Edward in 1955; at that time, N.-J. Chii and R. U. Lemieux began to study the anomerization equilibria of the fully acetylated derivatives of several aldohexopyranoses. The term “anomeric effect” was introduced in 1958.[2] The anomeric effect got its name from the term used to designate the C-1 carbon of a pyranose, the anomeric carbon. Isomers that differ only in the configuration at the anomeric carbon are called anomers.

he anomeric effect can be generalized to any system with the general formula R–Y–C–Z, where Y is an atom with one or more electronic lone pairs, and Z is an electronegative atom. The magnitude of the anomeric effect is estimated at about 1–2 kcal/mol in the case of sugars. In this general case, the molecule need not be cyclic. For example, a small molecule that exhibit the anomeric effect and that is often used for theoretical studies is dimethoxymethane. In the case of dimethoxyethane the gauche,gauche conformation is 3–5 kcal/mol about lower in energy (more stable) than the trans,trans conformation—this is about two times as big as the effect in sugars because there are two rotatable bonds that are affected.

Caffeine content of Caffeine content

Sunday, November 30th, 2008

For “regular” formula, a 10 oz. bottle of Bawls contains 64 mg of caffeine and a 16 oz. can has 103 mg of caffeine; a 16 oz. can of Bawls “Exxtra” contains 150 mg of caffeine. For reference, a 12 oz. can of Coca-Cola usually contains 34.5 mg of caffeine.[6]

Amylose

Sunday, November 30th, 2008

Amylose is a linear polymer of glucose linked mainly by ?(1?4) bonds. It can be made of several thousand glucose units. It is one of the two components of starch, the other being amylopectin.

The ?(1?4) bonds promote the formation of a helix structure. The structural formula of amylose is pictured at right. The number of repeated glucose subunits (n) can be many thousands (usually in the range of 300 to 3000).

Amylose starch is less readily digested than amylopectin; however, it takes up less space so is preferred for storage in plants: it makes-up about 30% of the stored starch in plants. The digestive enzyme amylase works on the ends of the starch molecule, breaking it down into sugars.

Iodine molecules fit neatly inside the helical structure of amylose, binding with the starch polymer that absorbs certain known wavelengths of light. Hence, a common test for starch is to mix it with a small amount of yellow iodine solution. In the presence of amylose, a blue-black color will be observed. The intensity of the color can be tested with a colorimeter, using a red filter to discern the concentration of starch present in the solution.

High-amylose varieties of rice have a much lower glycemic load, which could be beneficial for diabetics.

Culture of Bawls

Sunday, November 30th, 2008

Bawls has been targeting consumers in urban areas such as New York City, Chicago, Detroit, St. Louis and Kansas City as well as “gamers” and different kinds of sports, such as motorcross, BMX and paintball. Bawls also sponsored 24-Hour Comics Day, and gave away cases to comic stores holding the event.

Anomer

Sunday, November 30th, 2008

In sugar chemistry, an anomer is a special type of epimer. It is a stereoisomer (diastereomer, more exactly) of a saccharide (in the cyclic form) that differs only in its configuration at the hemiacetal (or hemiketal) carbon, also called the anomeric carbon. If the structure is analogous to one with the hydroxyl group on the anomeric carbon in the axial position of glucose, then the sugar is an alpha anomer. If, however, that hydroxyl is in the equatorial position, then the sugar is a beta anomer. For example, ?-D-glucopyranose and ?-D-glucopyranose, the two cyclic forms of glucose, are anomers. For -L- the ? and ? are contrarywise. (see Glycosidic bond for details)

The anomeric effect helps stabilize the ?-anomer. The term for interconversion between the two anomers is mutarotation.

The two different anomers are two distinct chemical structures, and thus have different physical and chemical properties, notably optical rotation. For example, ?-D-glucose has an optical rotation of +112 degrees and its anomer, ?-D-glucose, has an optical rotation of +19 degrees.