Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a human gene.
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name.
TRPC6 is a transient receptor potential ion channel associated with focal segmental glomerulosclerosis.
Transient receptor potential cation channel, subfamily C, member 4, also known as TRPC4, is a human gene encoding a protein of the same name.
Transient receptor potential cation channel, subfamily M, member 1, also known as TRPM1, is a human gene.
The protein encoded by this gene is similar to the transient receptor potential (Trp) calcium channel family members. The expression of this protein is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis[1]. The expression of the TRPM1 gene is regulated by the Microphthalmia-associated transcription factor
Among the functional responsibilities of the TRPM channels are:
regulation of calcium oscillations after T cell activation (TRPM4).[6]
sensory transduction in taste cells (TRPM5).
regulation of magnesium reabsorption in the kidneys and absorption in the intestines (TRPM6).[7]
regulation of cell adhesion (TRPM7).
The relative permeability of calcium and magnesium varies widely among TRPM channels.
TRPM4/5 are impermeable to calcium.
TRPM3/6/7 are highly permeable to both calcium and magnesium.
The mechanism of activation also varies greatly among TRPM channels.
TRPM2 is activated by ADP-ribose Adenosine 5′-diphosphoribose and functions as a sensor of redox status in cells.[3]
TRPM4/5 are activated by intracellular calcium.
TRPM8, conversely, can be activated by low temperatures, menthol, eucalyptol and icilin.
TRPM is a family of transient receptor potential ion channels where the “M” stands for “melastatin”.[1] Functional TRPM channels are believed to form tetramers.[2]
Unlike the TRPC and TRPV sub-families, TRPM subunits do not contain N-terminal ankyrin repeat motifs but, rather, contain entire functional proteins in their C-termini. TRPM6 and TRPM7, for example, contain functional ?-kinase segments, which are a type of serine/threonine-specific protein kinase.
Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a human gene encoding a protein of the same name.
Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is subtype of the TRPC family of mammalian transient receptor potential ion channels. Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin [1]. This activation probably plays a role in rheumatoid arthritis.
Transient receptor potential cation channel, subfamily C, member 4 associated protein, also known as TRPC4AP, is a human gene.