What is TRPM2
Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a human gene.
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Tags: Integral membrane proteins, Ion channels, Membrane proteins, Proteins, Transmembrane proteins
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The relative permeability of calcium and magnesium varies widely among TRPM channels.
TRPM4/5 are impermeable to calcium.
TRPM3/6/7 are highly permeable to both calcium and magnesium.
The mechanism of activation also varies greatly among TRPM channels.
TRPM2 is activated by ADP-ribose Adenosine 5'-diphosphoribose and functions as a sensor of redox status in cells.[3]
TRPM4/5 are activated by intracellular calcium.
TRPM8, conversely, can be activated by low temperatures, menthol, eucalyptol and icilin.