Transient receptor potential cation channel, subfamily M, member 4, also known as TRPM4, is a human gene encoding a protein of the same name.
Tags: Integral membrane proteins, Ion channels, Membrane proteins, Proteins, Transmembrane proteins
The relative permeability of calcium and magnesium varies widely among TRPM channels. TRPM4/5 are impermeable to calcium. TRPM3/6/7 are highly permeable to both calcium and magnesium. The mechanism of activation also varies greatly among TRPM channels. TRPM2 is activated by ADP-ribose Adenosine 5'-diphosphoribose and functions as a sensor of redox status in cells.[3] TRPM4/5 are activated by intracellular calcium. TRPM8, conversely, can be activated by low temperatures, menthol, eucalyptol and icilin.
Among the functional responsibilities of the TRPM channels are: regulation of calcium oscillations after T cell activation (TRPM4).[6] sensory transduction in taste cells (TRPM5). regulation of magnesium reabsorption in the kidneys and absorption in the intestines (TRPM6).[7] regulation of cell adhesion (TRPM7).