What is TRPM6
TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.[1]
Tags: Integral membrane proteins, Ion channels, Membrane proteins, Proteins, Transmembrane proteins
The investigation of the TRPM genes and proteins in human cells is an area of intense recent study and, at times, debate. Montell et al. (2002)[72] have reviewed the research into the TRP genes, and a second review by Montell (2003)[73] has reviewed the research into the TRPM genes. The TRPM family of ion channels has members throughout the metazoa. The TRPM6 and TRPM7 proteins are highly unusual, containing both an ion channel domain and a kinase domain (Figure 1.7). The role of the kinase domain brings about the most heated debate[73]. The activity of these two proteins has been very difficult
Among the functional responsibilities of the TRPM channels are: regulation of calcium oscillations after T cell activation (TRPM4).[6] sensory transduction in taste cells (TRPM5). regulation of magnesium reabsorption in the kidneys and absorption in the intestines (TRPM6).[7] regulation of cell adhesion (TRPM7).
TRPM is a family of transient receptor potential ion channels where the "M" stands for "melastatin".[1] Functional TRPM channels are believed to form tetramers.[2] Unlike the TRPC and TRPV sub-families, TRPM subunits do not contain N-terminal ankyrin repeat motifs but, rather, contain entire functional proteins in their C-termini. TRPM6 and TRPM7, for example, contain functional ?-kinase segments, which are a type of serine/threonine-specific protein kinase.
All forms of life require magnesium, and yet the molecular mechanisms of Mg2+ uptake from the environment and the distribution (transport) of this vital element within the organism are only slowly being elucidated. In bacteria Mg2+ is probably mainly supplied by the CorA protein[1] and, where the CorA protein is absent, by the MgtE protein[2][3]. In yeast the initial uptake is via the Alr1p and Alr2p proteins[4], but at this stage the only internal Mg2+ distributing protein identified is Mrs2p[5]. Within the protozoa only one Mg2+ transporter (XntAp) has been identified[6]. In metazoa, Mrs2p[7] and MgtE homologues[8] have been identified,